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Quantitation in 131 I‐radioimmunotherapy using spect
Author(s) -
Riggs Simon J.,
Green Alan J.,
Begent Richard H. J.,
Bagshawe Kenneth D.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410722
Subject(s) - nuclear medicine , imaging phantom , single photon emission computed tomography , radioimmunotherapy , spect imaging , correction for attenuation , emission computed tomography , medicine , attenuation , positron emission tomography , physics , optics , antibody , immunology , monoclonal antibody
Quantitation from planar imaging and single photon emission computed tomography (SPECT) were compared in phantom studies and in patients receiving therapeutic doses of 131 I‐labelled anti‐CEA. During the reconstruction of the data for SPECT quantitation attenuation correction and a correction for Compton scatter were used. The limitations of both methods were examined using the phantom studies and it was shown that practical SPECT quantitation could be achieved in patients given therapeutic doses of 131 I‐labelled anti‐CEA, and furthermore, that SPECT appeared to give a more accurate estimate of the activity concentration.