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Immunotherapy of pancreatic cancer with monoclonal antibody BW 494
Author(s) -
Schulz G.,
Büchler M.,
Muhrer K. H.,
Klapdor R.,
Kübel R.,
Harthus H. P.,
Madry N.,
Bosslet K.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410721
Subject(s) - medicine , immunotherapy , monoclonal antibody , pancreatic cancer , gastroenterology , cancer , antibody , pancreatic disease , progressive disease , chemotherapy , immunology , pancreas
In a phase I trial 34 patients with pancreatic cancer were treated with the murine monoclonal antibody (MAb) BW 494 (BI 51.011) directed against a glycoprotein antigen. The patients received repeated doses of MAb over a time period from 5 to 14 days (highest single dose 100 mg, highest cumulative dose 490 mg). During this treatment serum levels of murine lgG increased to 43.4 μg/ml. The serum half life of murine lgG ranged from 2 to 3 days. Repeated injections of MAb BW 494 were normally well‐tolerated when given within the first 15 days. Two patients presented with fatigue and a neuritis‐like syndrome 2 weeks after the last lgG infusion which had resolved spontaneously by the next day. Severe allergic reactions were observed in 3 patients after repeated injections of the MAb. These 3 patients had high levels of human anti‐murine antibodies (HAMA). Four weeks after the first application of MAb BW 494, 17/18 patients presented with HAMA (lgG). It could be demonstrated that the anti‐murine response was in part anti‐idiotypic. At the moment 16/34 patients are eligible for evaluation of tumor response. There was no complete or partial remission; however, 2 patients responded with minor tumor regression up to 32 weeks documented by reduction of liver metastases and primary tumor in CAT scan. Five additional patients presented with a long period of stable disease after immunotherapy (up to 40 weeks). Nine patients had progressive tumor disease in spite of MAb treatment.