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Absence, or low expression, of leukocyte adhesion molecules CDI1 and CD18 on burkjtt lymphoma cells
Author(s) -
Patarroyo Manuel,
Prieto Jacqueline,
Ernberg Ingemar,
Gahmberg Carl G.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410623
Subject(s) - cell adhesion molecule , lymphoma , adhesion , cd18 , biology , cell adhesion , pathology , cancer research , immunology , medicine , chemistry , genetics , cell , integrin , organic chemistry
Leukocyte adhesion to cells is mediated by the cell‐surface glycoprotein complex CDIIa‐c/CD18 and, in some cases, the glycoprotein gp84. The process is associated with leukocyte activation and modulates lymphocyte proliferation and maturation. Epstein‐Barr virus (EBV)‐transformed normal B lymphocytes give rise to lymphoblastoid cell fines (LCLs) which grow as large clusters mediated by adhesion molecules. In contrast, newly explanted EBV‐infected Burkitt lymphoma (BL) cells usually grow as single cells or as loose clusters. We now report that EBV positive‐ and EBV‐negative BL lines lack the adhesive protein complex, or have only low levels of it, whereas LCLs, representing various stages of B‐lymphocyte development, contain considerably higher amounts, as measured by immunofluorescence flow cytometry and immuno precipitation. The level of gp84 expression is of the same magnitude in both types of cells.