Premium
Vascular density in carcinoma of the uterine cervix and its predictive value for radiotherapy
Author(s) -
Siracka Eva,
Révész L.,
Kovač R.,
Siracký J.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410607
Subject(s) - radiation therapy , predictive value , medicine , uterine cervix , carcinoma , cervix , gynecology , radiology , cancer
The vascular density (VD) in stage‐III tumors of the uterine cervix was determined by morphometric analysis of histologic, Masson‐trichrome stained sections prepared from biopsies. In a retrospective study, VD was found to be related to results of radiotherapy, larger VD being associated with prolonged survival, in agreement with similar observations made earlier with stage‐IB and ‐IIA tumors of the cervix. In a complementary study the variation of VD within tumors was investigated in relation to the variation between tumors using surgically removed cervical carcinomas in stage IB. Statistically significant F‐ratios were calculated, suggesting a more or less individual pattern of vascularization of the tumors despite a considerable intra‐tumoral heterogeneity of the vas‐culature. It is concluded that VD may reflect oxygenation of neoplastic tissue, and may have a predictive value in regard to the response of tumors to irradiation.