Premium
A prospective study of esophageal cytological atypia in linxian county
Author(s) -
Lu JianBang,
Yang WenXian,
Dong WenZhou,
Sang JiuYuan
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410605
Subject(s) - atypia , medicine , incidence (geometry) , hyperplasia , gastroenterology , prospective cohort study , carcinoma , esophageal cancer , esophagus , statistical significance , cytology , cancer , pathology , physics , optics
Between I9TS and 1975, in Linxian county (LX), a prospective study of esophageal cytologrcal hyperplasia and atypia was conducted on 3 groups of subjects: 294 with marked atypia, 328 with mild hyperplasia and 336 normal controls; all were diagnosed by cytology. Results showed that no significant difference in incidence of esophageal cancer (EC) appeared between subjects with mild hyperplasia and controls, while the incidence of EC in subjects with marked atypia was 1,178.92/100,000 which was 2.39 (after age‐adjustment 2.90) times higher than that found in the control group and was of statistical significance (x 2 = 8.92, p < 0.01). In all groups, the relatively high risk of contracting EC was closely associated with drinking ground water, smoking and a low standard of living. These results suggest that early treatment should be given to subjects with marked atypia, accompanied by preventive measures against carcinoma of the esophagus, such as hygienic drinking water, abstention from smoking and better living conditions.