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Further studies on chromosome 15 trisomy in murine T‐cell lymphomas: Mapping of the relevant chromosome segment
Author(s) -
Silva Santiago,
Babonits Magda,
Wiener Francis,
Klein George
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410517
Subject(s) - trisomy , biology , chromosome , genetics , chromosome 21 , chromosome 3 , gene
Trisomy 15 is the most common chromosomal aberration in murine T‐cell lymphomas. The relevant chromosomal region responsible for the growth advantage of the 15‐trisomic cell has not been defined. In order to map this region, we have induced thymic lymphomas by chemical carcinogens (DMBA or MNU) in mice with 2 different constitutional translocations, T(7;15)9H homozygotes and [T(7;15)9H x T(5;15)4Ad] F 1 hybrids. Twenty‐two tumors developed in 90 carcinogen‐treated mice. Among the 14 cytogenetically analyzed thymic lymphomas, 4 were diploid and 5 were aneu‐ploid, with no chromosome‐15‐associated changes. Five lymphomas showed partial duplication of chromosome 15. Four of them have duplicated the segment distal to the C/DI breakpoint of T9H, while the 5th carried an interstitial duplication of the D2 sub‐band of the T(7;15) translocation chromosome. These findings suggest that the duplication of the D 2/3 region, known to contain the c‐myc and the pvt ‐1 genes (Banerjee et al. , 1985), rather than other regions of chromosome 15, contributes to the development and/or progression of murine T‐cell leukemias.