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Lymphoma‐specific T‐ and B‐cell responses suggest the involvement of HTLV‐I in virus‐non‐productive lymphomas of a married couple
Author(s) -
Schneider E. Marion,
Saal Johannes G.,
Mann Dean L.,
Pawelec Graham,
Schneider Josef,
Schlote Wolfgang,
Wernet Peter
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410413
Subject(s) - cytotoxic t cell , lymphoma , immunology , clone (java method) , biology , in vivo , adoptive cell transfer , t cell , il 2 receptor , cancer research , cd8 , immune system , lymphokine activated killer cell , medicine , interleukin 21 , in vitro , dna , biochemistry , genetics , microbiology and biotechnology
The occurrence of aberrant cellular progeny is not an infrequent event in vivo. Viral infections (Hanto et al. , 1981; Gallo, 1984) and/or failures in genetic programming during cell proliferarion may facilitate the manifestation of malignancy in states of incomplete immune surveillance. This is suggested by a high incidence of lymphoid malignancies in immunode‐pressed individuals, as for example after organ transplantation (Penn, 1981). Efficient cellular defense mechanisms which control malignant growth have been postulated. So far, MHC‐restricted, tumor‐specific cytotoxic T cells have not been identified in vivo. Moreover, effector cells with natural killer activity have not consistently been shown to function as general or specific anti‐tumor agents in vivo. Nevertheless, LAK cells are presently under investigation in adoptive immuno‐therapy for tumors. The concept of LAK‐cell treatment is based on the observation that high concentrations of interleu‐kin 2 (IL‐2) induce activation and proliferation of autologous, tumor‐specific cytotoxic cells (Hersey et al. , 1981; Lotze et al. , 1981). The most promising results have been obtained in mouse tumor models, whereas treatment of human diseases has rarely been successful (Rosenberg et al. , 1986). In the present report, high percentages of CD25‐positive T lymphocytes were detected in PB and LN cell suspensions of a patient with a B‐cell NHL. These T cells were successfully enriched in cultures containing low doses of IL‐2. The CTX mediated by these T‐cell lines and a single T‐cell clone derived from them was specific for autologous lymphoma cells as well as for the lymphoma cells from a different individual. Interestingly, an HTLV‐I‐infected tumor‐cell line was recognized also. The specific cellular as well as the humoral immune response. however, was drastically reduced following chemo‐ and radiotherapy. In contrast, non‐specific CTX mediated by aclivated NK‐like cells persisted.