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Aminoterminal propeptide of type III procollagen in serum—an indicator of clinical behavior of advanced ovarian carcinoma?
Author(s) -
Risteli Leila,
Kauppila Antti,
Mäkila UllaMaija,
Risteli Juha
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410316
Subject(s) - procollagen peptidase , protein precursor , ovarian carcinoma , medicine , carcinoma , endocrinology , oncology , pathology , ovarian cancer , biology , cancer , biochemistry , gene
In ovarian carcinoma, elevated serum concentrations of the aminoterminal propeptide of type‐Ill procollagen are related to the clinical stage of the disease and to the presence of ascites, which contains very high concentrations of the pro‐peptide. In a follow‐up of patients with advanced disease, favorable clinical course was associated with normalizing pro‐pep tide values, whereas in progressing disease the values increased several weeks before clinical progression. In stable disease the concentrations were constantly above the reference range. Laminin and type‐IV‐collagen‐related serum antigens were mostly within the reference range.