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Loss of alleles on chromosome 18 and on the short arm of chromosome 17 in polyploid colorectal carcinomas
Author(s) -
Monpezat J.Ph.,
Delattre O.,
Bernard A,
Grunwald D.,
Remvikos Y.,
Muleris M.,
Salmon R. J.,
Frelat G.,
Dutrillaux B.,
Thomas G.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410315
Subject(s) - polyploid , loss of heterozygosity , biology , chromosome , ploidy , genetics , zygosity , allele , gene
The zygosity of 19 colorectal carcinomas (either near‐diploid or polyploid) from patients known to be heterozygous for RFLPs located on chromosome 18 or on the short arm of chromosome 17 has been examined. In most cases, at least one allele was significantly under‐represented. The reason for the absence of complete loss of heterozygosity was investigated for 5 polyploid tumors. It was shown that the diploid component which, in these tumors, is essentially composed of non‐neoplastic cells, remains heterozygous as the polyploid component invariably loses heterozygotity. The results strongly suggest that many colorectal carcinomas originate from a single cell which had lost at least part of either chromosome 18 or of one short arm of chromosome 17, or both.