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Resistance to growth of the moloney lymphoma YAC in semi‐syngeneic graft recipients
Author(s) -
ÄhrlundRichthr Lars,
Klein Eva
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910410122
Subject(s) - hybrid , biology , strain (injury) , lymphoma , loss of heterozygosity , phenotype , microbiology and biotechnology , gene , genetics , immunology , allele , anatomy , botany
The growth of the Motoney‐virus‐induced lymphoma YAC was examined in its strain of origin, A, as well ax in 6 AF 1 hybrids, ALF 1 , AB6F 1 , ACBF 1 , AABYF 1 , AACAF 1 , and AASWF 1 , “Hybrid resistance”, i.e. , lower frequency of incidence of tumor takes compared to simultaneous A controls, was observed in all of the tested hybrids. The results with the H‐2‐congeneic hybrids AABYF 1 , AACAF 1 and AASWF 1 , indicated that H‐2 heterozygosity in itself was sufficient to exhibit hybrid resistance against YAC grafts. The A strain and its H‐2 congeneic AABYF 1 , AACAF 1 , and AASWF 1 , hybrids all had similarly low activity in NK assays. Thus, the elevated resistance detected in these H‐2 congeneic hybrids did nat correlate with NK activity. The rejection capacity of the ALF 1 , AB6F 1 , and ACBF 1 , hybrids correlated to their relatively higher NK activity, when compared to the NK low AABYF 1 , AACAF 1 , and AASWF 1 , hybrids. However‐, consideration of quantitative differences in between the hybrids which expressed elevated NK activity ( i.e. , ALF 1 , AB6F 1 , and ACBF 1 ,) shows that the rejection capacity did nat correlate with NK status. The hybrid with the strongest NK effect (ACBF 1 ) was the least resistant to YAC growth (27% palpable tumors), and the hybrid with the weakest NK effect (ALF 1 ) was the most resistant to YAC growth (7.2% palpable tumors).