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Stimulation by EGF of the growth of EGF receptor‐hyperproducing tumor cells in athymic mice
Author(s) -
Ozawa Soji,
Ueda Masakazu,
Ando Nobutoshi,
Abe Osahiko,
Hirai Masamichi,
Shimizu Nobuyoshi
Publication year - 1987
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910400523
Subject(s) - receptor , stimulation , epidermal growth factor , cell culture , biology , in vivo , medicine , cell growth , endocrinology , cell , cancer research , biochemistry , genetics
EGF receptor‐hyperproducing cells of squamous carcinoma origin were inoculated s.c. into the bilatero‐abdominal regions of athymic mice and a mini‐osmotic pump containing EGF was implanted on the back. After 2 weeks the tumors formed from 5 different cell lines in the presence of EGF weighed 3 to 6 times more than those formed in the absence of EGF. The cells recovered from these tumors maintained their original characteristics such as the amplified EGF receptor gene, high numbers of EGF receptors and a sensitivity to EGF‐mediated inhibition of growth in vitro. These results suggest that EGF plays an important role in promoting growth of squamous‐cell carcinoma in vivo .