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Growth of mammary epithelial cells in breast‐cancer biopsies correlates with egf binding
Author(s) -
Spitzer Eva,
Grosse Richard,
Kunde Dieter,
Eberhard Schmidt H.
Publication year - 1987
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910390302
Subject(s) - breast cancer , mammary gland , epithelium , biology , epidermal growth factor , cancer research , cancer , medicine , pathology , oncology , receptor
In order to understand the role of EGF in the development of human mammary epithelial tissue, we analysed the binding of 125 I‐EGF to sections of breast cancer biopsies. A mean specific 125 I‐EGF binding of 8.9 fmol per mg protein was estimated in thin sections of 17 breast cancer biopsies. Microautoradiographic analysis of 125 I‐EGF binding to the tissue sections was applied to demonstrate that EGF was bound predominantly to mammary epithelial cells. The binding was clearly correlated to the number of mitoses of mammary epithelial cells in the same samples. The highest EGF binding and proliferation rates were found in biopsies from breast cancer with axillary lymph‐node metastases.