Premium
Unusual cytogenetic findings in two patients with t(4;11) acute leukemia
Author(s) -
Testa Joseph R.,
Misawa Shinichi,
Pollak Avrom,
Leavitt Richard
Publication year - 1986
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910380611
Subject(s) - chromosomal translocation , leukemia , gene duplication , cytogenetics , biology , acute leukemia , karyotype , chromosome , genetics , cancer research , gene
Unusual cytogenetic findings are described in two patients with acute leukemia and rearrangements involving chromosomes 4 and 11. Both patients had clinical and phenotypic features often found in leukemia with t(4;11)(q21;q23). At initial diagnosis, one patient showed a standard t(4;11) with duplication of the 4q‐translocation derivative. The latter finding has been described previously in a few patients with t(4;11) in association with disease progression. By analogy with the Ph 1 chromosome in chronic myelogenous leukemia, duplication of the 4q‐suggests that this derivative is the critical recombinant in the t(4;11). The second patient has a novel complex translocation, t(4;11;15)(q21;q23;q21). Analysis of this variant trans‐location implies that the 11 q + is the consistent chromosome rearrangement in this type of leukemia. The apparent contradiction of the findings in these and other relevant reported cases reviewed here suggests that genes on both the 11q+ and 4q‐recombinant chromosomes are important, in either the etiology or the progression of this disease.