Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney | Zendy

Oosterwdk E. | Zendy; Ruiter D. J. | Zendy; Hoedemaeker Ph. J. | Zendy; Pauwels E. K. J. | Zendy; Jonas U. | Zendy; Zwartendijk I. | Zendy; Warnaar S. O. | Zendy

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Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney

Author(s) -

Oosterwdk E.,

Ruiter D. J.,

Hoedemaeker Ph. J.,

Pauwels E. K. J.,

Jonas U.,

Zwartendijk I.,

Warnaar S. O.

Publication year - 1986

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910380406

Subject(s) - immunoscintigraphy , monoclonal antibody , renal cell carcinoma , antibody , pathology , kidney , antigen , carcinoma , subclass , epithelioma , epithelium , biology , microbiology and biotechnology , cancer research , medicine , immunology , radioimmunotherapy , endocrinology

This report describes a monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC‐related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.

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