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Trisomy and tetrasomy for long arm of chromosome 1 in near‐diploid human endometrial adenocarcinomas
Author(s) -
Couturier J.,
Vielh P. H.,
Salmon R.,
Dutrillaux B.
Publication year - 1986
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910380104
Subject(s) - tetrasomy , karyotype , trisomy , aneuploidy , biology , ploidy , chromosome , breakpoint , isochromosome , adenocarcinoma , chromosome 7 (human) , microbiology and biotechnology , pathology , genetics , medicine , cancer , gene
Karyotypic analysis by R‐banding after short‐term culture, carried out on 7 cases of human endometrial adenocarcinoma, showed in 4 of these a trisomy or a tetrasomy for the long arm of chromosome I. In the 4 cases, these imbalances were due to rearrangements involving centromeric or para‐centromeric breakpoints: 46, XX,−16, + der(1q16p) t(1;16)(1p16q;1q16p); 46, XX,−21, + der(1q21q) t(1;21)(1p21p;1q21q);46, XX,−21, + der(21) t(1;21)(q11;p13); 48, XX, +2, + i(1q). Two other cases showed only a numerical aberration: 47, XX, + 10 and 47, XX, + 12. In the last case, only cells with apparently normal karyotype were seen. In the 4 cases with an anomaly of chromosome I, two normal I chromosomes coexisted with abnormal elements. This shows that the rearrangement very likely occurred in G 2 phase of the cell cycle.