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Potential carcinogenicity of Aza‐aromatic hydrocarbons: Azabenz(A)anthracenes
Author(s) -
Miao R. M.,
Tanga M. J.,
Suk W. A.,
Miller A.,
Reist E. J.
Publication year - 1986
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910370422
Subject(s) - anthracene , carcinogen , in vitro , chemistry , embryo , leukemia , microbiology and biotechnology , toxicology , biology , biochemistry , organic chemistry , immunology
The potential carcinogenicity of 3 azabenz(a)‐anthracenes was determined in vitro . The 3 compounds tested were 1‐, 2‐, and 9‐azabenz(a)‐anthracene. The initial assay was chemical carcinogen‐induced enhancement of anchorage‐independent survival of Rauscher leukemia virus‐infected Fischer rat embryo cells, 2FR 4 50 (2FR 4 ). Cells treated with 2‐ and 9‐azabenz(a)anthracene showed dose‐dependent increased survival. After continued subculturing, the surviving cells from 2‐ and 9‐azabenz(a)anthracenetreated cultures displayed morphological transformation and ability to grow in semi‐solid medium. Mocktreated controls and I‐azabenz(a)anthracene‐treated cultures did not show either of these properties. These data suggest that certain azabenz(a)anthracenes are potential carcinogens.