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Immunological consequences of tumor excision: From active immunity to immunological memory
Author(s) -
Bursuker Isia,
North Robert J.
Publication year - 1986
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910370216
Subject(s) - immunity , humoral immunity , fibrosarcoma , cyclophosphamide , cellular immunity , immunology , biology , monoclonal antibody , concomitant , immune system , antibody , medicine , chemotherapy , genetics
Excision of the immunogenic Meth‐A fibrosarcoma during generation by the host of concomitant antitumor immunity resulted in the appearance in sequence of two qualitatively distinct states of post‐excision immunity. Immunity expressed on the day of excision was dependent on Ly‐I − 2 + , cyclophosphamide‐sensitive T cells, whereas immunity expressed 2 weeks later was dependent on cyclophosphamide‐resistant T cells which can be functionally eliminated by either anti‐Ly‐1 or anti‐Ly‐2 monoclonal antibody and complement. The data suggest that antitumor immunity expressed shortly after tumor excision represents active concomitant immunity that is acquired by the host before excision is performed. In contrast, immunity expressed 2 weeks later is based on immunological memory.