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Mast cells and tumour angiogenesis: The tumour‐mediated release of an endothelial growth factor from mast cells
Author(s) -
Roche William R.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360617
Subject(s) - heparin , mast cell , angiogenesis , in vitro , neovascularization , endothelial stem cell , cell growth , biology , chemistry , immunology , microbiology and biotechnology , cancer research , biochemistry
Exposure to tumour cells has previously been shown to induce mast cells to degranulate and release heparin. Isolated mast‐cell granules were found to be mitogenic for endothelial cells in vitro . This effect was a property of mast‐cell heparin, whose potency as a mitogen exceeded that of commercial heparins. The basis of this difference lay in the proteoglycan structure of the molecule. The release of heparin in mastcell‐tumour co‐cultures was examined by both endothelial cell proliferation and isotopic techniques. The kinetics and mode of release are described. The results are discussed in relation to the role of the mast cell in angiogenesis assays and tumour neovascularization.