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The relationship between 17β hydroxysteroid dehydrogenase and breast tumour site and size
Author(s) -
Beranek P. A.,
Folkerd E. J.,
Newton C. J.,
Reed M. J.,
Ghilchik M. W.,
James V. H. T.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360611
Subject(s) - breast tumours , adipose tissue , hydroxysteroid dehydrogenase , dehydrogenase , medicine , pathology , mammary gland , endocrinology , enzyme , biology , breast cancer , cancer , biochemistry
The activity of 17β hydroxysteroid dehydrogenase (17OHSD) was measured in adipose tissue adjacent to benign or malignant breast tumours. 17OHSD activity was signficantly correlated with tumour size in malignant tumours (r = 0.75) but not with benign tumours (r = 0.28). Enzyme activity was reduced in adipose tissue adjacent to tumours obtained from inferior breast quadrants.