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The diagnostic value of a hepatoma‐specific band of serum gamma‐glutamyl transferase
Author(s) -
Xu KeCheng,
Meng XianYong,
Shi YiCai,
Ge ZhengJu,
Ye Ling,
Yu ZhiJian,
Yang DaMin
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360608
Subject(s) - gastroenterology , medicine , stage (stratigraphy) , metastasis , gamma glutamyltransferase , carcinoma , transferase , ampulla , pathology , cancer , chemistry , biology , enzyme , biochemistry , paleontology
Using a vertical slab electrophoretic apparatus loaded with polyacrylamide stage gel plate, we observed a total of II bands of gamma‐giutamyl transferase (EC 2.3.2.2, GGT) on a gel plate and designated these GGT I‐XI by order of distance beginning at the positive pole. Positive GGT II was found in 81(90%) of 90 cases of primary hepatic carcinoma (PHC), in 9(90%) of 10 cases of secondary hepatic carcinoma (SHC), and in only 4 (3.1 %) of a total of 128 cases of acute and chronic liver disease. There was one case with positive GGT II among 45 cases of cancer of ampulla of Vater, but the possibility of hepatic metastasis could not be excluded. No GGT II was found in a total of 250 healthy persons and 21 pregnant women. PHC patients with negative alpha‐fetoprotein (AFP) had a positive GGT II rate of 84.6%, whereas in those with negative GGT II the positive rate for AFP was only 44.4%.