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Possible association of a new translocation, t(7; 11)(p15;p15), with Ph 1 chromosome‐negative chronic myelogenous leukemia
Author(s) -
Kaneko Yasuhiko,
Maseki Nobuo,
Takasaki Nobuko,
Sakurai Masaharu,
Kawai Kazuo,
Sakurai Minoru
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360606
Subject(s) - chromosomal translocation , chronic myelogenous leukemia , leukemia , philadelphia chromosome , chromosome , cytogenetics , biology , immunology , medicine , genetics , gene
A Ph 1 chromosome‐negative chronic myelogenous leukemia (CML) with t(7;11)(p15;p15) in a 6‐year‐old girl is reported. Three cases of 7;11 translocation have been reported so far. The patients concerned were between 37 and 72 years of age; 2 of them had CML and the other had acute myelomonocytic leukemia. Data from these 4 cases suggest that the 7;11 chromosome translocation may be related to a subgroup of Ph 1 ‐negative CML, specifically to one that may easily proceed to blast phase, or to „subacute” myelogenous leukemia. The present case demonstrates that CML with this chromosome abnormality is not restricted to adults but also affects children. The t(1;11)(q21or23;p15) reported in another case with Ph 1 ‐negative CML may be a variant of this translocation.