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Expression of burkitt lymphoma‐associated antigen (defined by the monoclonal antibody 38.13) on both normal and malignant germinal‐centre B cells
Author(s) -
Murray L. J.,
Habeshaw J. A.,
Wiels J.,
Greaves M. F.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360508
Subject(s) - germinal center , monoclonal antibody , antigen , lymphoma , biology , follicular lymphoma , b cell , immunology , antibody , monoclonal , phenotype , pathology , cancer research , medicine , gene , genetics
Abstract Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (p k ) determinant expressed selectively on Burkitt and a few other B‐cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centres of secondary lymphoid follicles as well as to blood vessels. In malignant populations equivalent to various developmental compartments of the B‐cell lineage, only those with a follicular phenotype express the p k determinant at detectable levels. The expression of this tumour‐associated antigen, in common with many others, is therefore regulated in concert with cell lineage and maturation status.