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Elevated expression of the cellular SRC gene in tumors of differing etiologies in xiphophorus
Author(s) -
Schartl Manfred,
Schmidt CarlRudolf,
Anders Annerose,
Barnekow Angelika
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910360212
Subject(s) - xiphophorus , biology , etiology , pathology , malignancy , melanoma , cancer research , carcinogen , fish <actinopterygii> , gene , medicine , genetics , fishery
In the fish Xiphophorus we have detected elevated levels of pp60 c ‐ src kinase activity in a variety of tumors (n = 34) of neurogenic, epithelial, and mesenchymal origin either of hereditary etiology or induced by carcinogens. This elevation ranged from 2‐fold up to 50‐fold compared to the corresponding non‐tumorous tissue and up to 6‐fold compared to the highest activities found in any of the normal organs. The level of elevation parallels the degree of malignancy in melanoma and in tumors of mesenchymal origin. In fish bearing tumors of hereditary etiology kinase activity was also elevated in the non‐tumorous brain, while in fish bearing induced tumors, kinase activity was elevated only in the cells of the neoplasia.