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Characterization of murine hepatoma BW7756. III. Hematological profile of a tumor‐associated anemia
Author(s) -
Mizejewski G.,
Chao E.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350619
Subject(s) - reticulocytosis , leukocytosis , hematocrit , anemia , hemoglobin , medicine , endocrinology , transplantation , population , antibody , immunology , biology , andrology , environmental health
A severe anemia develops in recipient C57L/J mice after syngeneic transplantation of the BW7756 murine hepatoma. The tumor undergoes an exponential growth spurt in the 14–21 days post‐implantation, accompanied by a parallel increase in serum alpha‐feto‐protein levels and a significant decrease of hemoglobin concentration and hematocrit extending to the 28th day. Concomitant with the decreased hematocrit, the blood volume displayed a 10% increase. The blood cell population was generally one of reticulocytosis and leukocytosis. Mild icteric plasma was observed and both “cold” and “warm” antibodies were detected in the sera of tumor‐bearing mice. An elevation of IgM was observed by day 7, followed by a depletion of IgG 1 and IgG 2 throughout the tumor growth period. When RBCs of tumor‐bearing mice were compared to those of normal mice, the same degree of osmotic fragility was found. However, the lifespan of the transfused RBC was shorter in tumor‐bearing mice than in normal mice (half‐life: 2 days vs. 4 days). The data suggest a type of auto‐immune hemolytic anemia which is analogous to various hematopoietic disturbances described for murine hosts bearing solid tumors distal to hematopoietic sites.