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Oncogene expression in human tumors
Author(s) -
Tatosyan A. G.,
Galetzki S. A.,
Kisseljova N. P.,
Asanova A. A.,
Zborovskaya I. B.,
Spitkovsky D. D.,
Revasova E. S.,
Martin P.,
Kisseljov F. L.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350606
Subject(s) - oncogene , sarcoma , cancer research , nude mouse , biology , pathology , carcinoma , kidney , lymph , gene , medicine , cell culture , cell cycle , biochemistry , genetics , endocrinology
The expression of 9 oncogenes in primary tumors and in human tumors passaged in nude mice was tested: a total of 28 tumor types was analyzed. Oncogenes src, fps , and mos were not expressed in any of the tumors tested but oncogene myc was transcribed in most of the tumors and myc was overexpressed in 3 tumors passaged in nude mice (Ewing sarcoma, large intestine carcinoma and kidney carcinoma) and in primary fibrous histiocytoma. Enhanced transcription of ras and fos genes was observed nonspecifically in different tumors. Oncogene sis was activated specifically in metastases of different tumors in lymph nodes.