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A dual expression of cytokeratin and neurofilaments in bronchial carcinoid cells
Author(s) -
Lehto VeliPekka,
Miettinen Markku,
Virtanen Ismo
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350402
Subject(s) - neurofilament , intermediate filament , vimentin , cytokeratin , desmin , cytoplasm , cytoskeleton , pathology , biology , cell type , microbiology and biotechnology , cell , immunohistochemistry , medicine , biochemistry
Intermediate filaments (IF) are ubiquitous cytoplasmic structures which, by virtue of their cell‐ and tissue‐type‐specific characteristics, are widely used as markers of tissue derivation and as differential diagnostic aids in surgical pathology. In contradistinction to other IFs, vimentin filaments, characteristic of mesenchymal cells, may be coexpressed with other cell‐type specific IFs—cytokeratin filaments, desmin filaments, glial filaments and neurofilaments—in some tumor cells, embryonic cells, and cells in vitro . In this study we describe a novel type of IF coexpression which does not involve vimentin‐filaments, viz . the presence of both cytokeratin filaments and neurofilaments in human bronchial carcinoid tumor cells.