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Behaviour of dendritic reticulum cells possessing immunoreactive acid cysteine‐proteinase inhibitor in human lymphoid secondary follicles and in follicular‐centre cell lymphomas
Author(s) -
Alavaikko M.,
Aine R.,
Rinne A.,
Järvinen M.,
Blanco G.,
ApajaSarkkinen M.,
HopsuHavu V. K.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350307
Subject(s) - follicular phase , biology , immunohistochemistry , pathology , follicular dendritic cells , lymphoma , lymphatic system , follicular lymphoma , immunology , endocrinology , t cell , medicine , immune system , antigen presenting cell
In our previous studies acid cysteine‐proteinase inhibitor (ACPI) was shown to be a common characteristic of human squamous epithelia and dendritic reticulum cells (DRC) in lymphoid secondary follicles. In the present study, the behaviour of ACPI‐immunoreactive DRC in reactive lymphoid secondary follicles and neoplastic follicles of follicular‐centre cell (FCC) lymphomas was compared by the peroxidase‐antiperoxidase method. The secondary follicles in reactive lymphoid tissues revealed a staining pattern characteristic of DRC comparable with the results of other studies. Contrary to this, the number of ACPI‐positive DRC in the neoplastic lymphoid follicles was greatly reduced. This was occasionally accompanied by a weak reaction and in many cases the DRC were totally abolished. Moreover, morphological aberrations were observed in ACPI‐positive DRC, especially diminution and shortening of dendritic processes. On occasion, ACPI‐positive cell types were observed, which may represent intermediate forms between DRC and fibroblastic reticulum cells. Only one case‐with a rather favourable clinical outcome (out of 41 follicular FCC lymphomas) exhibited an ACPI‐positive DRC pattern comparable with that of reactive lymphoid follicles. Thus it seems that the ACPI‐immunohistochemistry of DRC provides an additional tool for discerning the difference between reactive and neoplastic lymphoid follicles. This method is of particular value since it can be used with formalin‐fixed, paraffinembedded tissues. There was a tendency among the follicular FCC lymphoma patients towards a better survival rate for those with ACPI‐positive DRC than for those lacking this cell type, although no statistically significant differences emerged from this limited material.