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Tissue carcinoembryonic antigen and estrogen receptor in human breast cancer
Author(s) -
Hartfiel Renate,
Lopes José Daniel,
Lopes Miriam T. P.,
Brentani M. Mitzi
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350204
Subject(s) - carcinoembryonic antigen , estrogen receptor , medicine , monoclonal antibody , breast cancer , antigen , mammary gland , immunofluorescence , estrogen , pathology , stage (stratigraphy) , antibody , oncology , cancer , biology , immunology , paleontology
Sixty‐six human ductal infiltrative breast carcinomas were examined for their estrogen receptor (ER) by the dextran‐coated charcoal procedure and for the presence of carcinoembryonic antigen (CEA) by immunofluorescence with the aid of monoclonal antibodies. Statistically significant differences in CEA positivity were found between stage III (33%) and stage II (19%) tumors (Z = 2.08; p < 0.02) and between ER + (22%) and ER – (37%) tumors (Z = 2.083; p < 0.02). An inverse correlation was observed between positivity and receptor concentrations. No difference in CEA positivity was observed between pre‐ and post‐menopausal women.