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AFP‐synthesis induction in mouse hepatomas
Author(s) -
Shipova L. Y.,
Gleiberman A. S.
Publication year - 1985
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910350121
Subject(s) - alpha fetoprotein , peripheral blood , pathology , biology , embryo , liver damage , medicine , endocrinology , cancer research , immunology , microbiology and biotechnology , hepatocellular carcinoma
Abstract Highly differentiated, spontaneous hepatomas occurring in 13‐ to 15‐month‐old CBA mice were unable to produce embryo‐specific serum protein alpha‐fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP‐positive cells were detected in two zones: (I) along the inflammatory shaft arising around the peripheral parts of incisions, and (2) near large blood vessels draining the damaged areas. It is suggested that mechanisms regulating AFP synthesis in highly differentiated hepatomas are similar to those of the normal liver and are related to local structural rearrangements.