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Subgroup analysis of BL‐cell lines with polyclonal bl‐specific antibodies
Author(s) -
Gazitt Yair,
EhlinHenriksson Barbro,
Lerner Ana,
Klein George
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910340615
Subject(s) - antibody , polyclonal antibodies , antigen , biology , calla , microbiology and biotechnology , cell culture , cytoplasm , virology , lymphoma , monoclonal antibody , immunology , genetics
A Burkitt's lymphoma (BL)‐specific antibody (antiGP70), previously described, was used to analyse 22 different BL‐cell lines. The results indicated specificity of antibodies to lines that contain both surface membrane Ig (Smlg) and cytoplasmic Ig (Cylg). BL‐cell lines derived from more immature B cells that do not have Smlg but rather have only Cylg were negative. A comparative study with antibody to common ALL antigen (CALLA) and to another BL‐specific antigen (BLA) revealed coexpression of GP70 with those two antigens, but no identity between them.