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Possible association between HLA‐DR5 and superficial spreading melanoma (SSM)
Author(s) -
MuellerEckhardt G.,
Schendel D. J.,
Hundeiker M.,
Riedel T.,
O'Neill G. J.,
Riethmüller G.,
MuellerEckhardt C.
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910340603
Subject(s) - haplotype , lentigo maligna , melanoma , superficial spreading melanoma , human leukocyte antigen , typing , medicine , pathology , biology , dermatology , immunology , genetics , genotype , antigen , gene
Previous analyses of possible associations between MHC determinants and cutaneous malignant melanoma (MM) have been inconclusive. We have investigated 98 patients with special emphasis on histologically determined subtypes of MM, and 5 multiple‐case families. In addition to HLA‐ABC and DR typing, complement allotypes of C2, C4A, C4B, BF were determined. Among the unrelated patients HLA‐DR5 and, secondarily, B49 were observed to be associated with superficial spreading (SSM) but not with nodular (NM) or lentigo maligna melanoma (LMM). In families with MM, no definite segregation of the disease according to HLA and complement haplotypes was discernible. Moreover, no coincidence of haplotypes occurred in patients of the different families. HLA region recombinations including B/DR and/or DR/GLO were found in all the families investigated.