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Monocyte activation in patients with Hodgkin's disease
Author(s) -
Kávai Maria,
Berßnyi Ernö,
Zsindely Attila,
Szegedi Gyula,
Fésüs Läszlö
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910340409
Subject(s) - lysozyme , tissue transglutaminase , mononuclear phagocyte system , monocyte , disease , medicine , enzyme , stage (stratigraphy) , immunology , gastroenterology , pathology , biology , biochemistry , paleontology
Transglutaminase activity in monocytes and serum lysozyme level were tested in 40 patients with Hodgkin's disease and were found to be significantly increased. Transglutaminase activity in monocytes from patients in a clinicaly active stage of the disease was higher than in clinically inactive cases of HD, and varied along with the histological subtypes. Serum lysozyme varied with the stage of the disease and with the symptomatology as well as with the histological subtype. The enzyme activities were higher before any treatment than after. A parallel increase of transglutaminase activity in monocytes and of serum lysozyme level suggests an elevated activity of the mononuclear phagocyte system in Hodgkin's disease.