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The ability to concentrate iodide as a marker of hormone dependence in GR mouse mammary tumors
Author(s) -
Thorpe Susan M.,
Briand Per
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910340122
Subject(s) - iodide , hormone , medicine , endocrinology , transplantation , mammary gland , chemistry , biology , cancer , breast cancer , organic chemistry
We have previously shown that hormone‐dependent (HD) but not hormone‐independent (HI) mammary tumors of GR mice concentrate iodide. Since hormone dependence is lost during serial transplantation of the tumors, we have investigated whether the ability to concentrate iodide is lost simultaneously. All tumors progressing to hormone independence lost the ability to concentrate iodide at the time of transition from the HD to the HI state. We believe, therefore, that the ability to concentrate iodide is a marker of hormone dependence in GR mouse mammary tumors.