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Preparation and properties of a mouse monoclonal antibody (W14A) to human chorionic gonadotropin
Author(s) -
Searle F.,
Partridge C. S.,
Kardana A.,
Green A. J.,
Buckley R. G.,
Begent R. H. J.,
Rawlins G. A.
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330402
Subject(s) - human chorionic gonadotropin , choriocarcinoma , monoclonal antibody , radioimmunoassay , luteinizing hormone , gonadotropin , antibody , g alpha subunit , chemistry , medicine , endocrinology , microbiology and biotechnology , biology , hormone , protein subunit , immunology , biochemistry , gene
Abstract A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta‐subunit, showing less than 2% cross‐reactivity towards the alpha‐subunit and 0.5% cross‐reactivity towards the beta‐subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.