Preparation and properties of a mouse monoclonal antibody (W14A) to human chorionic gonadotropin | Zendy

Searle F. | Zendy; Partridge C. S. | Zendy; Kardana A. | Zendy; Green A. J. | Zendy; Buckley R. G. | Zendy; Begent R. H. J. | Zendy; Rawlins G. A. | Zendy

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Preparation and properties of a mouse monoclonal antibody (W14A) to human chorionic gonadotropin

Author(s) -

Searle F.,

Partridge C. S.,

Kardana A.,

Green A. J.,

Buckley R. G.,

Begent R. H. J.,

Rawlins G. A.

Publication year - 1984

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910330402

Subject(s) - human chorionic gonadotropin , choriocarcinoma , monoclonal antibody , radioimmunoassay , luteinizing hormone , gonadotropin , antibody , g alpha subunit , chemistry , medicine , endocrinology , microbiology and biotechnology , biology , hormone , protein subunit , immunology , biochemistry , gene

A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta‐subunit, showing less than 2% cross‐reactivity towards the alpha‐subunit and 0.5% cross‐reactivity towards the beta‐subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.

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