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Detection of the granulocyte‐specific antigen 3‐fucosyl‐ N ‐acetyl‐lactosamine on leukemic cells after neuraminidase treatment
Author(s) -
Tetteroo P. A. T.,
Van Veer M. B. T,
Tromp J. F.,
von dem Borne A. E. G. Kr
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330312
Subject(s) - neuraminidase , granulocyte , antigen , immunology , biology , medicine , virus
The carbohydrate antigen 3‐fucosyl‐ N ‐acetyl‐lactos‐amine (FAL) is expressed on human granulocytes and is detected by a monoclonal antibody B4.3. After neuraminidase treatment, this structure can also be detected on monocytes and on the cells of nearly all acute myeloid leukemia patients (38/39). It is then also present on the cells of a number of CALLA‐positive lymphatic leukemias (8/18), but not on T‐ALL and B‐ALL cells. On cells of patients with AUL, the antigen is then detected in many TdT + cases, but not in TdT − cases.