Detection of the granulocyte‐specific antigen 3‐fucosyl‐ N ‐acetyl‐lactosamine on leukemic cells after neuraminidase treatment | Zendy

Tetteroo P. A. T. | Zendy; Van Veer M. B. T | Zendy; Tromp J. F. | Zendy; von dem Borne A. E. G. Kr | Zendy

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Detection of the granulocyte‐specific antigen 3‐fucosyl‐ N ‐acetyl‐lactosamine on leukemic cells after neuraminidase treatment

Author(s) -

Tetteroo P. A. T.,

Van Veer M. B. T,

Tromp J. F.,

von dem Borne A. E. G. Kr

Publication year - 1984

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910330312

Subject(s) - neuraminidase , granulocyte , antigen , immunology , biology , medicine , virus

The carbohydrate antigen 3‐fucosyl‐ N ‐acetyl‐lactos‐amine (FAL) is expressed on human granulocytes and is detected by a monoclonal antibody B4.3. After neuraminidase treatment, this structure can also be detected on monocytes and on the cells of nearly all acute myeloid leukemia patients (38/39). It is then also present on the cells of a number of CALLA‐positive lymphatic leukemias (8/18), but not on T‐ALL and B‐ALL cells. On cells of patients with AUL, the antigen is then detected in many TdT + cases, but not in TdT − cases.

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