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In vitro antibody‐dependent cellular cytotoxicity against human T‐cell leukemia/lymphoma virus (HTLV)‐producing cells
Author(s) -
Miyakoshi Hideo,
Koide Hiroko,
Aoki Tadao
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330302
Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , antibody , immunology , leukemia , antigen , peripheral blood mononuclear cell , virology , natural killer cell , cytotoxic t cell , biology , in vitro , monoclonal antibody , biochemistry
Human T‐cell leukemia/lymphoma virus (HTLV)‐producing cells were lysed by peripheral mononuclear cells (PMNC) from both anti‐HTLV antibody‐positive and ‐negative healthy persons in the presence of natural humoral antibodies against HTLV‐related antigens (antibody‐dependent cellular cytotoxicity, ADCC). PMNC from patients with T‐cell leukemia, however, did not possess the positive reaction even in the presence of natural antibodies. In contrast, when the antibodies were absent, no cytotoxicity was caused by PMNC from any donors. Additionally, the complement present in the antibody‐positive plasma did not contribute to humoral antibody‐dependent cytotoxicity in the presence of plasma without PMNC. Therefore, ADCC against HTLV‐producing cells may correlate with the prophylaxis of HTLV‐induced malignancy in vivo .