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Immunological responses to a murine mammary adenocarcinoma. outgrowth of pulmonary occult metastases induced by immunosuppressive perturbations
Author(s) -
Yamamura Yasuhiro,
Braunschweiger Paul G.,
Ramananda Madyastha K.,
Proctor Julian W.
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330113
Subject(s) - occult , adenocarcinoma , pulmonary adenocarcinoma , medicine , mammary carcinoma , mammary gland , pathology , cancer research , oncology , immunology , cancer , carcinoma , breast cancer , alternative medicine
Intravenously (i.v.) or subcutaneously (s.c.) injected T1699 tumor cell subpopulations (Ts, and TL1–1) were destroyed more rapidly in BALB/c nu/nu athymic mice than in syngeneic DBA/2J mice. The number of artificial pulmonary metastases of TL1–1 tumors was significantly lower, and the growth rate of s.c. Ts, and TL1–1 tumors was correspondingly slower in the nude mice. No macroscopic outgrowth of pulmonary metastases of Ts tumors was detected in either group of s.c. tumor‐bearers, even though the s.c. tumors progressed and killed the hosts. Unexpectedly, however, s.c. implantation in normal DBA/2J mice of lung homogenates not only from DBA/2J but also from s.c. Ts tumor‐bearing BALB/c nu/nu mice produced tumors, suggesting that significant numbers of clonogenic Ts cells were present in the lungs of animals without spontaneous outgrowth of pulmonary metastases. Perturbations of s.c. Ts tumor‐bearing DBA/2J or BALB/c nu/nu mice with immunosuppressive drugs or with anti‐mouse thymocyte serum, respectively, induced rapid outgrowth of pulmonary metastases.