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Enhanced chemotaxis of tumor‐derived and virus‐transformed cells to fibronectin and fibroblast‐conditioned medium
Author(s) -
Mensing Hartwig,
Albini Adriana,
Krieg Thomas,
Pontz Bertram F.,
Müller Peter K.
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330109
Subject(s) - chemotaxis , fibronectin , fibronectins , fibroblast , fibrosarcoma , ht1080 , cell culture , biology , metastasis , microbiology and biotechnology , matrix (chemical analysis) , chemistry , extracellular matrix , cancer research , cancer , biochemistry , receptor , genetics , chromatography
SV40 transformants of human embryo fibroblasts showed an enhanced chemotactic response to fibronectin and conditioned medium of fibroblasts in comparison to the non‐transformed cells. An even higher chemotactic response was characteristic for a malignant human fibrosarcoma cell line, whereas cells derived from low‐grade malignant dermatofibrosarcoma showed a normal response in the Boyden chamber assay. The high stimulation of chemotaxis is paralleled by a reduced synthesis and an altered deposition of fibronectin in the pericellular matrix of these cells. Both high chemotactic response and lack of deposition of fibronectin may play a role in tissue invasion and formation of metastasis by malignant tumors.