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Estrogen binding sites on membranes from human laryngeal papilloma
Author(s) -
Essman Eric J.,
Abramson Alan
Publication year - 1984
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910330107
Subject(s) - papilloma , membrane , estrogen , estrogen receptor , larynx , epithelium , estrogen receptor beta , biology , pathology , chemistry , medicine , endocrinology , biochemistry , cancer , anatomy , breast cancer
Estrogen binding sites were identified on plasma membranes from biopsy materials (N=16) of normal human larynx; such binding was found to be specific. In tissue from 22 cases of laryngeal papilloma, membrane binding of 17‐beta‐estradiol was also specific. Although such binding occurred for papilloma membranes at a comparable affinity, it was clear that all membranes from the papillomatous tissue possessed a 148% greater estrogen binding capacity; there were at least 17 times more estrogen binding sites for each mg of receptor protein on papilloma membrane than for normal laryngeal epithelium. These findings suggest a possible receptor marker for the detection and/or prediction of recurrence of laryngeal papilloma.