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Effects on metastases of drug therapy during developing and established tumor immunity
Author(s) -
Vaage Jan,
Costanza Mary E.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320617
Subject(s) - cyclophosphamide , methotrexate , immunity , medicine , immune system , chemotherapy , cellular immunity , fluorouracil , immunology , cancer research , drug , drug resistance , lewis lung carcinoma , pharmacology , cancer , biology , metastasis , microbiology and biotechnology
Abstract The effectiveness of treatment with cyclophosphamide, methotrexate and 5‐fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5‐fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with estatablished tumor immunity gave added benefit without detectable depression of immune resistance.