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Endotoxin‐induced in vitro release of interleukin‐1 by cancer patients' monocytes: Relation to stage of disease
Author(s) -
Pollack Simon,
Micali Anita,
Kinne David W.,
Enker Warren E.,
Geller Nancy,
Oettgen Herbert F.,
Hoffmann Michael K.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320613
Subject(s) - medicine , colorectal cancer , breast cancer , cancer , melanoma , stage (stratigraphy) , disease , oncology , in vitro , metastasis , interleukin 6 , mammary gland , immunology , cytokine , gastroenterology , cancer research , biology , paleontology , biochemistry
The in vitro release of IL‐I by monocytcs in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL‐I release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.