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A prospective study of urinary androgen levels and ovarian cancer
Author(s) -
Cuzick Jack,
Bulstrode J. C.,
Stratton I.,
Thomas B. S.,
Bulbrook R. D.,
Hayward J. L.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320611
Subject(s) - androsterone , androgen , dehydroepiandrosterone , medicine , urinary system , ovarian cancer , percentile , urine , physiology , endocrinology , gynecology , cancer , hormone , steroid , statistics , mathematics
The three major urinary androgen metabolites, dehydroepiandrosterone (DHEA), androsterone (ANDRO), and aetiocholanolone (AETIO) were measured in 1,484 volunteer women between 29 and 60 years of age on the island of Guernsey from 1962–1967. Twelve of these women subsequently developed ovarian cancer after a median interval of 130 months and a minimum interval of 19 months. All three androgen levels in these women were lower than those in controls matched for age and menopausal status. The results were most striking for DHEA, where half of the cases were below the 27th percentile of their matched controls ( p = 0.007, two‐sided). The results for ANDRO were of marginal significance ( p = 0.06), and those for AETIO were not significant ( p = 0.033).