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Increased antibody responses to Herpes virus papio (HVP) ANTIGENS IN PRE‐LYMPHOMATOUS BABOONS ( Papio hamadryas ) of the sukhumi high lymphoma stock
Author(s) -
Voevodin A. F.,
Yakovleva L. A.,
Lapin B. A.,
Ponomarjeva T. I.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320519
Subject(s) - lymphoma , antigen , titer , population , virus , antibody , biology , immunofluorescence , virology , immunology , antibody titer , pathology , medicine , environmental health
Antibody responses to Herpes virus papio (HVP) antigens were studied in 21 pre‐lymphoma baboons (which subsequently died of malignant lymphoma), 21 paired controls, i.e. age‐, sex‐ and population‐matched healthy baboons, and 185 randomly selected healthy baboons of the same population. The sera were all collected at the same time and were tested blind in the fixed‐cell indirect immunofluorescence test against HVP viral capsid antigen (VCA)‐positive, early antigen (EA)‐positive cell targets before and after absorption with HVP. Eleven of the pre‐lymphoma sera were anti‐EA‐positive whereas none of the paired controls contained anti‐EA. Anti‐VCA titers of pre‐lymphoma sera were higher than those of paired controls in thirteen cases. Only in four cases were anti‐VCA titers of pre‐lymphoma sera lower than those of paired controls. Qualitatively, the same results were obtained when anti‐VCA and anti‐EA titers of pre‐lymphoma sera were compared with respective mean population values. The differences between pre‐lymphoma group and control groups, especially in the case of anti‐EA, were statistically highly significant. Thus, elevated anti‐HVP titers in healthy baboons of the Sukhumi lymphoma‐prone stock can be considered as a marker of high risk for development of malignant lymphoma.