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Estrogen and progesterone receptor titers in primary epithelial ovarian carcinomas
Author(s) -
Jones L. A.,
Edwards C. L.,
Freedman R. S.,
Tan M. T.,
Gallager H. S.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320508
Subject(s) - estrogen , estrogen receptor , titer , endocrinology , medicine , progesterone receptor , menopause , ovary , ovarian carcinoma , receptor , cytosol , menarche , hormone , biology , ovarian cancer , breast cancer , cancer , immunology , antibody , biochemistry , enzyme
Only 69% (42 of 61) of the documentated ovarian tumor specimens received between September 1981 and August 1982 contained 75% or more viable tumor. Of the 42 measured for estrogen receptors (ER) and progesterone receptors (PR), 34 (81%) had estrogen‐binding titers. ⩾1 fmol/mg of cytosol protein, while 18 (43%) had progesterone‐binding titers ⩾5 fmol/mg of cytosol protein. ER and PR titers were found to be independent of histologic grade, clinical stage, patient age, age at first pregnancy, age at menarche, age at menopause and number of pregnancies. The presence of ER and PR in malignant ovarian tumors suggests that assays positive for these hormones could aid in the selection of patients suitable for hormonal therapy.