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Human lung tumour cell line adapted to grow in serum‐free medium secretes angiogenesis factor
Author(s) -
Kumar S.,
West D.,
Daniel Mary,
Hancock Anne,
Carr T.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320412
Subject(s) - angiogenesis , cell culture , secretion , biology , lung , immunology , pathology , cancer research , medicine , endocrinology , genetics
A human lung tumour cell line has been grown in serum‐free medium for 12 months and during this period cells were subcultured every 4 days. The culture medium contained an angiogenesis factor which has been purified and shown to be similar to that isolated from other sources including solid tumours. This is the first report that demonstrates de novo synthesis and secretion of angiogenesis factor by a cell line adapted to grow in a serum‐free medium.