Chromosomal aberrations in a case of T‐cell CLL with concomitant IgA myeloma | Zendy

Zech L. | Zendy; Hammarström L. | Zendy; Smith C. I. E. | Zendy

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Chromosomal aberrations in a case of T‐cell CLL with concomitant IgA myeloma

Author(s) -

Zech L.,

Hammarström L.,

Smith C. I. E.

Publication year - 1983

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910320406

Subject(s) - multiple myeloma , concomitant , clone (java method) , biology , bone marrow , malignancy , chronic lymphocytic leukemia , immunology , leukemia , pathology , medicine , genetics , dna

Four consistent markers, involving chromosomes 8, 11, 14, 18, 21 and 22, were found in the majority of meta‐phases obtained after stimulation of peripheral blood and bone marrow from a patient with a T‐cell chronic lym‐phocytic leukemia (CLL) and a concomitant IgA/lambda myeloma with phytohemagglutinin (PHA), lipopolysac‐charide of E. coli(LPS) and S. aureus strain Cowan I bacteria (Cowan). A second malignant clone with three additional markers was observed after stimulation with Con‐canavalin A (Con A). A chromosome 14 aberration, inv(14) (q11‐q32), may be of significance in the T‐cell malignancy and may suggest a common clonal origin of the two tumors.

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