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Human T‐cell leukemia virus type I: Induction of syncytia and inhibition by patients' sera
Author(s) -
Nagy Károly,
Clapham Paul,
CheingsongPopov Rachanee,
Weiss Robin A.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320310
Subject(s) - syncytium , cell fusion , virology , biology , leukemia , virus , serology , t cell leukemia , antibody , antigen , human t lymphotropic virus 1 , viral envelope , cell culture , cell , glycoprotein , microbiology and biotechnology , immunology , biochemistry , genetics
HTLV‐producing T‐cell lines induce cell fusion when cocultivated with a wide variety of indicator cells, suggesting that HTLV envelope antigens interact with the membranes of many cell types. Serum antibodies from adult T‐cell lymphoma‐leukemia (ATL) patients inhibited the formation of syncytia, and sera from British, American and Japanese ATL patients inhibited cell fusion induced by American and Japanese HTLV isolates equally well. No serological cross‐inhibition of syncytium induction was found between HTLV and bovine leukosis virus, Moloney murine leukemia virus and simian sarcoma‐associated virus. A simple syncytium inhibition test in microtiter plates has been developed to provide a rapid screen for antibodies presumed to be specific to HTLV envelope glycoproteins.