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Histopathological study on N ‐ethyl‐ N ′‐nitro‐ N ‐nitrosoguanidine‐induced colon cancer in dogs
Author(s) -
Kamano Toshiki,
Kishino Hiroshi,
Mizukami Ken,
Azuma Noboru,
Tamura Junji,
Katami Atsuo,
Kidokoro Tsutomu
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320219
Subject(s) - colorectal cancer , cancer , medicine , nitro , pathology , chemistry , alkyl , organic chemistry
We prepared a suppository containing 50 mg of N ‐ethyl‐ N ′‐nitro‐ N ‐nitrosoguanidine (ENNG), and successfully produced experimental colon cancer with good reproducibility by continuous intrarectal insertion of one or two suppositories per day in dogs. The tumors were very similar to human colon cancers, macroscopically and histologically. In one of three dogs subjected to histopathological study, metastases to the lymph nodes, lung, liver and kidney were observed. This animal model produced by a simple procedure will be helpful in investigating treatment of rectal cancer.