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Protective effect of butylated hydroxytoluene against induction of gastric cancer by N ‐methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine in wistar rats
Author(s) -
Tatsuta Masaharu,
Mikuni Tomiko,
Taniguchi Haruo
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320218
Subject(s) - butylated hydroxytoluene , carcinogen , methylnitronitrosoguanidine , hyperplasia , medicine , cancer , oral administration , stomach , nitrosamine , endocrinology , pharmacology , antioxidant , chemistry , biochemistry , mutant , gene
The effects of butylated hydroxytoluene (BHT) on the incidence and histology of gastric cancers induced by oral administration of N ‐methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine (MNNG) were investigated in Wistar rats. Oral administration of 1.0% BHT in regular chow pellets during treatment with MNNG for 25 weeks significantly reduced the incidence of gastric cancers in experimental week 40. BHT had no influence on the histological type of adenocarcinomas induced in MNNG‐treated rats. BHT alone induced slight glandular hyperplasia, but not moderate glandular hyperplasia or gastric cancer.