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Genetic control of immune responses to moloney sarcomas in rats: Role of non‐RT‐1 background genes
Author(s) -
Jones Joe M.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910320214
Subject(s) - immune system , antigen , bone marrow , biology , antibody , immunology , gene , ratón , genetics
Bone marrow chimeras, athymic nude rats and a congeneic strain were utilized to verify and further examine non‐RT‐I linked background genes that influence immune responses of BN and LEW rats to Moloney sarcomas. In transplants that did not involve RT‐I incompatibility, infusion of high‐responder bone marrow into a lethally irradiated low‐responder recipient, or low‐responder bone marrow into a high‐responder recipient, would restore a high antibody response to the gp70 antigen of MuLV. Such transplants did not restore a high response to the p30 antigen. Athymic nude rats did not exhibit a significant response to either p30 or gp70 while euthymic littermates exhibited a significant response to both antigens. Growth of Moloney sarcomas as well as antibody and cellular responses to antigens expressed by such tumors were measured in LEW‐IN rats which carry the RT‐I of BN and the background of LEW. For each of these parameters, LEW‐IN resembled LEW more closely than BN.